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Seafood Allergy Diagnosis

Seafood Allergy Diagnosis Research

The Department of Paediatrics is conducting a research study on diagnostic methods for shellfish allergy. We will use new molecular and cellular allergy tests to detect specific IgE antibodies against allergens derived from shellfish (crustaceans and mollusks) commonly consumed in Hong Kong. Shellfish includes: shrimp (seawater and freshwater shrimp), crab, scallop , mussels, clams, lobster, oysters and abalone.


We are now recruiting subjects who meet the following criteria to participate in our research:

- history of allergic reactions to shellfish

- children or adults aged 0-50 years

- presented immediate allergic reactions within 2 hours (such as urticaria, non-tubular swelling, wheezing, anaphylactic shock) upon shellfish ingestion


For eligible participants, we will arrange:

- an appointment to the Prince of Wales Hospital for a physical examination to determine the condition of allergies to shellfish

- collection of 8-10ml of whole blood for allergy blood test

- skin prick test

After completing the tests, we will provide written report of shellfish allergy test results.


If you meet the above requirements and are interested in participating in this research, please fill out the questionnaire at the following link:


If you have any questions regarding this research study, please call /WhatsApp at 5614-9123, or email us at


Thank you for your participation! Please also help to disseminate this message to people you know.

*Directly translated from the Chinese version


You may find out more about Dr. Christine Yee Yan Wai's research at the 2018 "Share Your AXA Research" event through the videos below:

1. Share Your AXA Research | Dr. C Yee Yan Wai: A DNA Vaccine for Shellfish Allergy | AXA Research Fund

2. Can a DNA Vaccine Beat a Shellfish Allergy? | AXA Research Fund

3. A Year in Review | Building the Future | AXA Research Fund

Read More

CUHK Press Release: CU Medicine proves basophil activation test has much higher diagnostic accuracy for shrimp allergy than conventional allergy tests

CUHK Press Release: CU Medicine Studies Suggest Grass Carp as a Major Source of Fish Allergy in Hong Kong And Identify Novel Allergenic Marker Cten i 1 to Promote Accurate Diagnosis

RTHK English: [Hong Kong Today] Hundreds of HK children allergic to fish (start from 1:06:08)

TVB Pearl: [7:30 News] CUHK Medicine Fish Allergy study (start from 09:12)

Apple Daily

Oriental Daily News

Wen Wei Po


  1. Wai CYY, Leung NY, Leung ASY, Shum Y, Leung PS, Chu KH, Kwan YW, Lee QU, Wong JS, Lam IC, Li PF, Xu KJ, Lam CY, Sun JL, Wong GW, Leung TF. Cell-based functional IgE assays are superior to conventional allergy tests for shrimp allergy diagnosis. The Journal of Allergy and Clinical Immunology: In Practice 2020; DOI: 10.1016/j.jaip.2020.08.057

  2. Wai CYY, Leung NYH, Chu KH, Leung PSC. Animal models of allergic disease. Humana Press, Totowa 2020; [in press]

  3. Leung NYH, Leung ASY, Xu KJY, Wai CYY, Lam CY, Wong GWK, Leung TF. Molecular and immunological characterization of grass carp (Ctenopharngodon Idella) parvalbumin Cten i 1: A major fish allergen in Hong Kong. Paediatric Allergy and Immunology 2020; doi:10.1111/pai.13259

  4. Wai CYY, Leung NYH, Chu KH, Leung PSC, Leung ASY, Wong GWK, Leung TF. Overcoming shellfish allergy: How far have we come? International Journal of Molecular Sciences 2020; 21, 2234.

  5. Leung ASY, Leung NYH, Wai CYY, Xu KJY, Lam MCY, Shum YY, et al. Characteristics of Chinese fish-allergic patients: Findings from double-blind placebo-controlled food challenges. The Journal of Allergy and Clinical Immunology: In Practice. 2020; 8: 2098-100.

  6. Wai CYY, Leung NYH, Leung PSC, Chu KH. Modulating shrimp tropomyosin-mediated allergy: hypoallergen DNA vaccines induce regulatory T cells to reduce hypersensitivity in mouse model. International Journal of Molecular Sciences 2019; 20: 4656.

  7. Wai CYY, Qin J, Leung NYH, Leung PSC, Chu KH. IgE signaling repression by a designer DNA vaccine to modulate shrimp hypersensitivity. European Medical Journal Allergy and Immunology 2019; 4: 69-71

  8. Leung NYH, Wai CYY, Chu KH, Leung PSC. Mimotope-based allergen-specific immunotherapy: ready for prime time? Cell and Molecular Immunology 2019; 16: 890-891. =

  9. Leung ASY, Leung NYH, Wai CYY, Leung TF, Wong GWK. Allergen immunotherapy for food allergy from the Asian perspective: key challenges and opportunities. Expert Review in Clinical Immunology 2019; 15: 153-164.

  10. Wai CYY, Leung NYH, Leung PSC, Chu KH. Immunotherapy of food allergy: a comprehensive review. Clinical Reviews in Allergy & Immunology 2019; 57: 55-73

  11. Tong WS, Yuen AWT, Wai CYY, Leung NYH, Chu KH, Leung PSC. Diagnosis of fish and shellfish allergies. Journal of Asthma and Allergy 2018; 11: 247-260. [IF=3.730]

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